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Lupus nephritis is an inflammation of the kidneys caused by lupus. With lupus nephritis, kidneys lose the ability to function properly to remove waste from the blood and control the fluids in your body. The disease can lead to serious health problems, permanent kidney damage, and even kidney failure.

Early signs and symptoms of lupus nephritis can be subtle or inconsistent and often overlap with other diseases so there may be few signs that anything is wrong. But common signs and symptoms include swelling (usually in the legs, feet, or ankles), foamy, frothy, or sudsy urine, hematuria (blood in urine), and protein in the urine (called proteinuria). If you think you are experiencing symptoms of lupus nephritis, talk to your doctor.

A lupus nephritis diagnosis is usually made by a nephrologist or a rheumatologist. It is often diagnosed through use of a urine test (to look for protein or blood in the urine), a blood test, and/or a kidney biopsy. Talk to your doctor about routine urine and blood testing, which can help catch lupus nephritis early and start to determine a treatment plan.

LUPKYNIS is the first FDA-approved oral medication specifically for adults with active lupus nephritis.

LUPKYNIS is indicated for use in adults with active lupus nephritis, but not everyone with lupus nephritis should take LUPKYNIS. Talk to your doctor to see if LUPKYNIS is right for you.

People taking cyclophosphamide should not take LUPKYNIS. If you are pregnant or are planning to be pregnant, are currently breastfeeding or are planning to breastfeed, talk to your doctor about your options before starting your treatment plan. LUPKYNIS should not be taken with medicines known as strong CYP3A4 inhibitors such as ketoconazole, itraconazole, and clarithromycin. Do not take LUPKYNIS if you are allergic to voclosporin or any ingredients in LUPKYNIS.

LUPKYNIS helps stop the attack of lupus nephritis and helps protect the kidneys from further irreversible damage.

LUPKYNIS works to calm your immune system, which is causing your body to attack the cells of your kidneys. It helps reduce inflammation and protect specific cells of the kidneys to keep them functioning.

LUPKYNIS was tested in clinical studies that involved more than 350 people across different races and ethnicities.

We created a downloadable doctor discussion guide so you can feel confident and prepared to talk to your doctor about LUPKYNIS. Get yours here.

If you have questions specifically about LUPKYNIS or any other aspects of your lupus nephritis treatment, you should always talk to your doctor. You can also enroll in Aurinia Alliance, a support program from Aurinia, the makers of LUPKYNIS, to be connected with a dedicated Nurse Case Manager. A personally assigned Nurse Case Manager (NCM) will provide the consistency and expertise needed to help you navigate your LUPKYNIS treatment journey. Sign up here to get started. You can also enroll by calling 1-833-AURINIA (1-833-287-4642).

Your Aurinia Alliance team focuses on providing you with what you need every step of the way on your LUPKYNIS treatment journey. Whether it's educational tools, help understanding your insurance and funding options, or just a friendly ear, we understand that your lupus nephritis journey is unique and we are here to listen and support you along the way. Your team includes one-on-one support from a dedicated Nurse Case Manager who will check in with you on a regular basis to answer your questions and see how you are doing, and a specialty pharmacy that will deliver LUPKYNIS directly to you.

Sign up here. You can also enroll by calling 1-833-AURINIA (1-833-287-4642).

When you enroll with Aurinia Alliance, you'll be paired with a Nurse Case Manager. They will be your dedicated contact throughout your LUPKYNIS treatment journey to help you stay organized and on track with your treatment. If you're interested in enrolling, sign up here and a dedicated Nurse Case Manager will contact you with more information. You can also enroll by calling 1-833-AURINIA (1-833-287-4642).

Everyone’s situation is different, but when you enroll with Aurinia Alliance, your Nurse Case Manager will partner with you and walk through all the options available to you based on your individual coverage.

Aurinia also offers a copay program for eligible commercial patients. $0 copay for eligible commercial patients.

97% of the time*, patients paid less than $10 for their LUPKYNIS prescription. Sign up here to get started. You can also enroll by calling 1-833-AURINIA (1-833-287-4642).

*97% of the shipments of LUPKYNIS delivered cost the patient $10 or less. These are patients on commercial insurance, Medicaid or Medicare from January 2022 to December 2022.

You should always take LUPKYNIS as directed by your doctor. A standard dose of LUPKYNIS is 23.7 mg (three 7.9 mg capsules) taken orally twice a day. Do not break, crush, chew, or dissolve LUPKYNIS capsules before swallowing. Although this is the standard dose, you should always take the recommended dose that is prescribed to you by your doctor. Each dose should be taken 12 hours apart, at the same time each day. LUPKYNIS should be taken on an empty stomach, either 1 hour before eating or 2 hours after eating, unless your doctor tells you otherwise.

To maintain the quality of the capsule, it’s important to remember to never take your LUPKYNIS capsules out of the blister pack until you’re ready to take them and to not put LUPKYNIS in another container. If you’re going to be away from home when it’s time to take your next dose, plan ahead and bring your packaged LUPKYNIS capsules with you.

If you've missed a dose, take it as soon as possible within 4 hours of the dose you missed. If more than 4 hours have passed since missing your dose, wait until the next scheduled time to take the next dose, but do not double the dose to make up for the one you missed.

Side effects included diarrhea, headache, cough, urinary tract infection, stomach pain, heartburn, and loss of hair (alopecia). These are not all the possible side effects of LUPKYNIS. Talk to your doctor about any side effects you may be experiencing. Please see the full list of possible side effects in the Prescribing Information, including Boxed Warning, and Medication Guide.