Registration

Taking LUPKYNIS

What to expect when taking LUPKYNIS

When you take LUPKYNIS as prescribed by your doctor, it can help maintain your kidney function.

While taking LUPKYNIS, routine visits with your doctor help them stay informed about your treatment progress and kidney function, and can also help them keep track of your symptoms.

Urine tests (urinalysis) monitor protein levels (proteinuria) and blood (hematuria) in the urine. Proteinuria is one of the key signs of active lupus nephritis.

Blood tests are used to check how well your kidneys are working

Routine visits ensure you're still on track with your treatment

With Aurinia Alliance®, your personalized support program, you'll be connected with a dedicated Nurse Case Manager who will be here with you every step of the way on your LUPKYNIS treatment journey. It's easy to enroll—click here to learn more about the one‑on‑one support you'll receive and get started today.

See how LUPKYNIS is helping people

Malisha, Suriya and Jennifer are fighting back against lupus nephritis — watch their stories to see how LUPKYNIS helps them do it.

How to take lupkynis

  • LUPKYNIS is an oral medication for the treatment of adults with active lupus nephritis.
  • LUPKYNIS must be swallowed whole on an empty stomach as close to 12 hours apart as possible (with at least 8 hours between doses)
  • If you miss a dose, take it as soon as possible within 4 hours after missing the dose.
  • If it's been longer than 4 hours, wait until the usual scheduled time to take your next regular dose—do not double your next dose.

Before starting LUPKYNIS, talk to your doctor about all the medications you are currently taking. Your doctor will determine the right dosage for you when prescribing LUPKYNIS. They will monitor you throughout the course of your treatment and may also change your dose. Always take LUPKYNIS as directed by your doctor.

A dosing schedule that fits into your life, not the other way around

Taken by mouth, not by injection

A standard dose is 3 capsules, 2x a day

Dosage schedule stays the same throughout treatment

I started taking 3 capsules twice a day and often set alarms on my phone to help me remember to take them, keeping me on track. I usually take the capsules in the morning and after dinner with a glass of water and I am loving the results I am receiving.

LUPKYNIS safety

Feel informed about treatment

LUPKYNIS was tested in clinical studies that involved more than 350 people across different races and ethnicities.

LUPKYNIS can cause serious side effects, so it's important to talk to your doctor right away if you experience any of these signs or symptoms.

The most common side effects of LUPKYNIS are diarrhea, headache, cough, urinary tract infection, stomach pain, heartburn, and loss of hair (alopecia). These are not all the possible side effects of LUPKYNIS. For more information, talk to your doctor.

Feel confident talking to your doctor about LUPKYNIS

Our downloadable doctor discussion guide can help make starting the conversation easier.

Connect with someone who's been there

Lupus Nephritis Peer ConnectTM is a mentorship program that allows you to speak with someone who may understand what you're going through. Our peer mentors volunteer for one-on-one calls to answer your questions, offer encouragement, and share their own personal experiences with lupus nephritis and treatment with LUPKYNIS.

Important Safety Information

LUPKYNIS® (voclosporin) can cause serious side effects, including:

  • Increased risk of cancer. People who take LUPKYNIS have an increased risk of getting some kinds of cancer, including skin and lymph gland cancer (lymphoma). Limit and avoid exposure to sunlight and UV light such as tanning machines. Wear protective clothing and use a sunscreen.
  • Increased risk of infection. LUPKYNIS is a medicine that affects your immune system. LUPKYNIS can lower the ability of your immune system to fight infections. Serious infections can happen in people taking LUPKYNIS that can lead to hospitalizations and can cause death. Call your healthcare provider right away if you have symptoms of an infection such as fever, sweats or chills, cough or flu-like symptoms, muscle aches, or warm, red, or painful areas on your skin.

Do not take LUPKYNIS with medicines known as strong CYP3A4 inhibitors such as ketoconazole, itraconazole, and clarithromycin, or if you are allergic to any of the ingredients in LUPKYNIS. You should not eat grapefruit or drink grapefruit juice while taking LUPKYNIS.

Before you use LUPKYNIS, tell your healthcare provider about all your medical conditions, including if you:

  • Plan to receive any vaccines. You should not receive any live vaccines during treatment with LUPKYNIS. Other vaccines may not work as well during treatment with LUPKYNIS.
  • Have or have had liver, kidney, or heart problems.
  • Have high blood pressure.
  • Are pregnant or plan to become pregnant or are breastfeeding or plan to breastfeed when taking LUPKYNIS. When taking LUPKYNIS in combination with mycophenolate mofetil, read the Medication Guide for mycophenolate mofetil for important pregnancy information. These medicines can harm your unborn or breastfed baby.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. LUPKYNIS may affect the way other medicines work, and other medicines may affect how LUPKYNIS works.

LUPKYNIS may cause serious side effects, including:

Kidney problems. Kidney problems are common side effects of LUPKYNIS and may be serious. Your healthcare provider may do certain tests to check your kidney function while you take LUPKYNIS.

High blood pressure. High blood pressure is a common side effect of LUPKYNIS and may be serious. Your healthcare provider will monitor your blood pressure while you take LUPKYNIS and may ask you to check your blood pressure at home.

Nervous system problems. Nervous system problems are a common side effect of LUPKYNIS and may be serious. Call your healthcare provider or go to the nearest hospital emergency room right away if you have any of these symptoms while taking LUPKYNIS:

  • confusion
  • changes in alertness
  • muscle tremors
  • numbness and tingling
  • headache
  • seizures
  • vision changes

High levels of potassium in your blood. Your healthcare provider may do certain tests to check your potassium levels while you take LUPKYNIS.

A serious heart rhythm problem (QT prolongation).

Severe low red blood cell count (anemia). Your healthcare provider may check your labs while using LUPKYNIS.

The most common side effects of LUPKYNIS are diarrhea, headache, cough, urinary tract infection, stomach pain, heartburn, and loss of hair (alopecia).

These are not all the possible side effects of LUPKYNIS. For more information, ask your healthcare provider. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to www.fda.gov/medwatch.

What is LUPKYNIS?

LUPKYNIS is a prescription medicine used with other medicines to treat adults with active lupus nephritis. LUPKYNIS should not be taken with a medicine called cyclophosphamide. Talk with your healthcare provider if you are not sure if you take this medicine.

Please see Prescribing Information, including Boxed Warning, and Medication Guide for LUPKYNIS.